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Mice with increased adult hippocampal neurogenesis show normal object recognition, spatial learning, contextual fear conditioning and extinction learning but are more efficient in differentiating between overlapping contextual representations, which is indicative of enhanced pattern separation

These effects work together with TNF-alpha inhibition to reduce inflammatory changes in the intestine and reduce colonic infiltration

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[25] WS patient samples and WS animal models NAD+-deficient cells showed impaired mitophagy (selective degradation of defective mitochondria)