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When PLOOH is not rapidly neutralized as an PLOH by glutathione peroxidase 4 (GPX4) in time, PLOOH further reacts with ferrous ions, and the resulting lipid radicals, such as alkoxyl phospholipid radicals (PLO) and PLOO, react with PUFA-PLs ( 2 produced by the mitochondrial tricarboxylic acid (TCA) cycle and the reduction of nitrogen oxides by NADPH produce H 2 O 2 catalyzed by superoxide dismutase (SOD) and participate in the Fenton reaction of iron ( Figure 1A )

doi: 10.3390/nu9111211 98 PiskinECianciosiDGulecSTomasMCapanogluE

Report any undesirable side effects to the doctor promptly

[16,98] A randomized crossover trial in humans looked at the effect of selenium (4000 mcg/day from four days before until four days post-chemotherapy) on the toxicity of cisplatin