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(12) used Cre-lox technology to delete the gene encoding the GLP-1R specifically in the CNS (nestin- Cre Glp1r fl/fl mice) or in the peripheral nervous system ( Phox2b-Cre Glp1r fl/fl mice)

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The recent launch of the new Ombion Center for animal-free biomedical innovations is a demonstration of major investments by the Dutch government to build an infrastructure offering research, education, training, advice and support to enhance the acceptance and use of animal-free biomedical innovations (323)

Therapeutic potential of semaglutide, a newer GLP-1 receptor agonist, in abating obesity, non-alcoholic steatohepatitis and neurodegenerative diseases: a narrative review