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For compound 2, truncation of a large portion (28-48 residues) of the N-terminal -helix resulted in a dramatic efficacy decrease of compound 2, implying the role of the tip of N-terminal -helix in the ago-allosterism

Consider ketone monitoring in patients with type 1 diabetes mellitus and in others at risk for ketoacidosis

Dhillon S, Keam SJ

Microdosing GLP-1 may be a good fit for: Patients who have experienced side effects with standard GLP-1 dosing Individuals starting GLP-1 medications for the first time Those who prefer a more gradual approach to weight management Patients navigating hormonal or metabolic changes , such as menopause Individuals with sensitive digestion or lower tolerance to medications Some patients may benefit more from standard dosing, particularly when a more structured or intensive approach is needed