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Bolinger AM, Zangwill AB, Slattery JT, Risler LJ, Sultan DH, Glidden DV et al

underlying medical disorders can contribute to weight gain and play a significant role in any weight management program

Reduce oxidative stress exposure as much as possible: UV rays, too much alcohol, UV damage, smoking, stress, and more

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This is the same mechanism that supports tissue repair, but it is a meaningful contraindication for anyone with active or recent malignancy