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NICE recommends it (Technology Appraisal TA875) for adults with a BMI of 35 kg/m or above with at least one weight-related comorbidity, or a BMI of 3034.9 kg/m in certain higher-risk groups, when used within a specialist Tier 3 or Tier 4 weight management service alongside a reduced-calorie diet and increased physical activity
Growth hormone inhibits its own secretion by acting on the hypothalamus through its receptors on neuropeptide Y neurons in the arcuate nucleus and somatostatin neurons in the periventricular nucleus
Miguens-Gomez et al, 2021
The trapezius, for example, extends down the back and helps in shrugging the shoulders, while the splenius capitis assists in extending and rotating the head
doi: 10.7150/IJBS.93120 96
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