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Factors influencing outcomes: Starting BMI Dietary adherence, particularly avoiding high-calorie liquids and grazing Regular follow-up at 3, 6, and 12 months, then yearly Engagement with dietitian support Some weight regain is common after several years, typically 1025% of the weight lost

Inflation Reduction Act provisions may also limit costs but implementation timelines remain uncertain

The effectiveness of Semaglutide GLP-1 can vary depending on factors such as starting weight, lifestyle, and other medications

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Conversely, a retrospective analysis reported fewer adverse reactions, improved QoL, and longer survival with NAC 600 mg TID + pirfenidone versus pirfenidone + budesonide (143)