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Community observations should inform but not replace careful individual risk assessment

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All patients in the STEP trials received counselling regarding diet (typically, 500 kcal deficit per day relative to the estimated total energy expenditure calculated once at randomization) and physical activity (100 minutes to 150 minutes of physical activity per week, depending on the study)

Between 2014 and 2015, the authors identified a total of 2,928 opioid-related overdoses in Massachusetts, and 2,244 (77%) that had accompanying toxicology results

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