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The aberrant GM may lead to increased production of amyloid proteins and LPS, increased intestinal permeability, and allow the entry of inflammatory molecules across the blood-brain barrier and thus cause neuroinflammation and neuronal damage (272, 273)

Monitor your body for changes Pay attention to how your body reacts over time

Users hope to limit side-effects, such as vomiting, cut the cost and experience other health benefits, despite the low dose

The most common drug-related adverse events were nausea, constipation and vomiting

For example, PAE not only protects against AS but also exerts neuroprotective effects by inhibiting neuronal ferroptosis in cerebral hemorrhage (Wei et al., 2023)