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It is a severe form of dysautonomia (dysfunctional autonomic nervous system) and can cause many uncomfortable or even painful symptoms, including: Dizziness or lightheadedness Fainting or near fainting Forgetfulness or brain fog Heart palpitations Exhaustion/fatigue Shortness of breath Chest pains Headaches Feeling anxious or nervous Shakiness or excessive sweating Bloating Nausea A pale face and purple discoloration of your hands and feet, if theyre lower than the level of your heart If symptoms are severe, patients manage their symptoms through prescription medications, but sometimes medications do not work or are simply not an option for some patients

Development of a direct contact astrocyte-human cerebral microvessel endothelial cells blood-brain barrier coculture model

Int J Mol Sci (2021) 23:337

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