The pharmacokinetics also explain why blood levels rise gradually and reach steady state after ~45 weekly doses, at which point effects feel more consistent
[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Butler J, Shah SJ, Petrie MC, Borlaug BA, Abildstrm SZ, Davies MJ, Hovingh GK, Kitzman DW, Mller DV, Verma S, Einfeldt MN, Lindegaard ML, Rasmussen S, Abhayaratna W, Ahmed FZ, Ben-Gal T, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Melenovsk V, Merkely B, Nez J, Perna E, Schou M, Senni M, Sharma K, van der Meer P, Von Lewinski D, Wolf D, Kosiborod MN STEP-HFpEF Trial Committees and Investigators
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