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Insulin has stimulatory effects on ovarian androgen production 5,11 , and enhances the bioavailability of testosterone by decreasing the hepatic release of sex hormone-binding globulin (SHBG) 12

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Commercial models that fail to account for abandonment and discontinuation risk significantly overestimating return on investment (ROI )

Laboratory Abnormalities Liver Enzymes Increases in alanine aminotransferase (ALT) greater than or equal to 10 times the upper limit of normal were observed in 5 (0.15%) SAXENDA-treated patients (two of whom had ALT greater than 20 and 40 times the upper limit of normal) compared with 1 (0.05%) placebo-treated patient during the SAXENDA clinical trials

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