After reaching the 1mg maintenance phase, some patients may increase to 1.5mg or 2.4mg weekly based on clinical goals and tolerability
Phase 2 clinical trials published in 2023 reported mean resting heart rate increases of approximately 5 to 7 beats per minute at higher doses (8 mg and 12 mg weekly)
Adjustments are based on your response to treatment, health history, and overall goals to ensure your plan continues to support your health safely
Call Your Provider Promptly For Severe abdominal pain (possible pancreatitis) Persistent vomiting that prevents fluid intake Right-upper-quadrant pain that radiates to the back or shoulder (possible gallbladder issue) Sudden vision changes (rare, but reported) Symptoms of severe dehydration: dizziness on standing, dark urine, dry mouth For a deeper dive on what to expect over time, our side effect timeline guide walks through duration and management for each common issue
Reported side effects include: Nausea and queasiness , especially after meals during the first few weeks of dosing