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Thus, they began studying the use of GLP-1 agonists as weight loss medications

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

The primary comparators of interest were all licensed doses of injectable GLP-1 RAs approved for the treatment of T2Donce-weekly dulaglutide, twice-daily exenatide, once-weekly exenatide extended-release, once-daily liraglutide, once-daily lixisenatide, and once-weekly injectable semaglutide