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Tirzepatide: The First GLP-1/GIP Dual Agonist Tirzepatide is a dual incretin agonist that activates both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors and was developed to enhance metabolic and weight-loss outcomes beyond those achieved with GLP-1 receptor agonists alone

Modulatory metaplasticity induced by pregnenolone sulfate in the rat hippocampus: a leftward shift in LTP/LTD-frequency curve

In these cases, provider evaluation must address whether baseline thyroid function is stable, TSH is well-controlled, and whether introducing a GLP-1 agent poses any incremental autoimmune risk for that individual

It also contributes to macrophage M2 polarization, further amplifying the fibrotic response [32]

Henderson, H