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& Tan, I
Chronic tissue inflammation and metabolic disease
Unlike other forms of regulated cell death, cuproptosis is characterized by the direct binding of reduced copper (Cu + ) to lipoylated proteins of the tricarboxylic acid (TCA) cycle, most notably dihydrolipoamide S-acetyltransferase (DLAT), together with destabilization of iron-sulfur (Fe-S) cluster proteins such as succinate dehydrogenase complex ironsulfur subunit B (SDHB) 164
However, neuronal thiol oxidation (a measure of cellular oxidative stress) was not increased in our live whole mount preparations following treatment with BSO, suggesting that in situ inhibition of GSH synthesis does not affect cellular thiol state
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