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We should not be using obesity pharmacotherapy or surgery in those who do not have the disease of obesity and thus the benefits will outweigh any of those risks if utilized in the indicated patient population.

Furthermore, it is important to recognise that the predicted absolute benefit of an intervention is dependent on the absolute risk and thus those with prior CVD events are more likely to experience a benefit over intermediate time frames than those with cardiovascular risk factors only

It may help improve insulin resistance, which can in turn help regulate testosterone levels

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Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans