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Efficacy The efficacy of tirzepatide was assessed in the SURMOUNT clinical trial program, which included 4 phase 3 studies: SURMOUNT-1, -2, -3 and -4

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Consistent with this notion, a recent study reported that membrane-bound O-acyltransferase domain containing1 and 2 (MBOAT1/2), which is regulated by ER, inhibits ferroptosis through phospholipid remodeling independently of GPX4 [23]

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