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In the official clinical guidelines of the American Thoracic Society for the role of weight management in the treatment of adults with OSA it was stated that individuals with BMI 27 kg/m 2 (in whom body weight has not been improved despite lifestyle modifications) can be evaluated for anti-obesity pharmacotherapy, although currently there is insufficient evidence to recommend any pharmacotherapy [31, 32]

& Avliyakulov, N.K

165,166 Exercise regimens incorporating mixed modalities, such as swimming and interval training, further enhance mitophagy, reducing oxidative stress, apoptosis, and inflammatory signaling in preclinical models

doi:10.1007/pl00012378

Despite appearing promising, as the prevalence of diabetes in patients with dementia is around 1320% [66] whether the findings from diabetic patients apply to the wider AD population is debatable