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While it is generally accepted that opioid withdrawal is not fatal, iatrogenic precipitated withdrawal may be much more severe resulting in clinically significant autonomic hyperactivity with consequences such as pulmonary edema and make patients more reticent to continue with future medication for opioid use disorder

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More clinical trials with larger sample sizes and combinations with other lipid peroxidation biomarkers would help to draw more solid conclusions

B1 (niacin) is known to cause flushing I believe