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MT-2 activates two distinct melanocortin receptor subtypes MC1R and MC4R producing effects that span skin pigmentation, sexual function, appetite regulation, body composition, and neuroprotection

Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected