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It has been reported that the prevalence of HFpEF is steadily increasing due to the aging of population and the global prevalence of obesity and T2DM [16, 17]

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By inhibiting the Gas proteins and facilitating receptor trafficking through internalization and recycling, these beta arrestins are essential for GIP receptor desensitization

Nature (2002) 418(6893):419.10.1038/nature00870 55 SanzCVazquezPBlazquezCBarrioPAAlvarezMMBlazquezE

doi: 10.1016/j.molmet.2021.101180 209 KellyPMcCleanPLAckermannMKonerdingMAHolscherCMitchellCA