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For orforglipron, participants initiated on higher doses and those on rapid titration schemes appeared to have higher discontinuation rates, providing insights into the optimisation process for the phase 3 trials

10.1038/s41571-020-00462-0 17 ChengQ.BaoL.LiM.ChangK.YiX

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Current recommendations for water intake offered by the Mayo Clinic suggest women should consume about 11.5 cups per day (2.7 liters), and men should consume about 15.5 cups per day (3.7 liters)