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In preclinical models of neurodegeneration, GLP-1R agonists reduce amyloid plaque formation, improve neuronal survival, and reduce neuroinflammation

The contraction is that isolated porcine coronary artery rings induced by KCl, histamine, 5-hydroxytryptamine, and extracellular Ca 2+ (Zhang et al., 2009)

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The available human evidence is limited to early phase-2 studies on postoperative ileus, as reported by Beck et al., 2014, and has not led to any authorisation