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Further insight into the effects of semaglutide in patients who receive background SGLT2 inhibitors will be provided by the STEP-HFpEF DM trial, which includes a greater proportion (32%) of patients taking these agents 12

Choline prevents hepatic steatosis (fatty liver) by enabling phosphatidylcholine synthesis, the lipid transport molecule that shuttles triglycerides out of liver cells into circulation for oxidation or storage elsewhere

The study found that surgery after GLP-1 treatment was associated with significant additional weight loss, supporting the idea that medication and surgery may be used as part of a staged treatment pathway

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