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However, research into transdermal patches combined with penetration enhancers or microneedle arrays is exploring whether sustained peripheral delivery can achieve sufficient systemic levels to produce CNS effects for highly potent compounds

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The relative level of p70S6K1 or p70S6K2 mRNA was determined by comparison of p70S6K1 or p70S6K2 mRNA in each polysomal fraction to that in the corresponding free RNAs fraction, respectively, using the formula 2 [Ct(polysomal fraction)Ct(free RNAs fraction)]