retatrutide phase 2 nejm weight loss 48 weeks triple agonist Dosing Guide: 1-12 mg Weekly (2026) Triple G Agonists – Retatrutide.

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if you become pregnant whilst on treatment, stop the medication and seek immediate medical and nutritional review [1] [25] Contact your GP urgently if you experience: Severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis Upper-right abdominal pain, fever or jaundice which may suggest gallbladder disease Persistent nausea or vomiting preventing adequate nutrition Signs of dehydration (dark urine, dizziness, reduced urination) Unexplained symptoms such as jaundice, severe fatigue, or mood changes For people with diabetes: hypoglycaemia (low blood sugar) symptoms when taking insulin or sulfonylureas alongside GLP-1 therapy Regular monitoring throughout GLP-1 treatment should include periodic assessment of weight, body composition where possible, nutritional intake, and relevant blood markers

Most participants on 8 mg and 12 mg reached major weight loss milestones, including at least 1015% weight loss