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Tight Junctions as Modulators of Intestinal Integrity and Paracellular Translocation The paracellular transport of important molecules across the intestinal epithelium is regulated by transmembrane and intracellular proteins that interlink to form TJs

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Targeting inflammatory pathways, specifically the NLR family pyrin domain containing 3 (NLRP3)/IL-1/IL6/C-reactive protein (CRP) pathway, has emerged as another strategy for improving cardiorenal outcomes in high-risk populations

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the mechanism/target terms included "gut microbiota" OR "intestinal microbiome" OR "metabolomics" OR "metabolism" OR "short chain fatty acids" OR "SCFAs"