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Beta-cell mass and turnover in humans: effects of obesity and aging

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The in vivo study showed a significant reduction in TMAO levels in C57BL/6(FMO3 +/+ ) strain WT mouse models and in TMA levels in C57BL/6 -Fmo3em1Smoc (KO) mouse models

Before steady state, each weekly injection adds to the accumulating pool but you have not yet reached the plateau where effects are maximized

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