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The cardiovascular outcomes trial SUSTAIN-6, which enrolled over 3,000 patients with type 2 diabetes at high cardiovascular risk, actually demonstrated cardiovascular benefits with semaglutide, including reduced rates of major adverse cardiovascular events

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Significant reductions in MI risk were observed in individuals with T2DM (Class IV

Despite the most recent studies of transgenic and germ-free animals, it is still largely unknown by what degree hormones such as GLP-1, and all its related peptides, depend on the microflora, especially in pathologies such as type 2 diabetes

Plant Physiol Biochem 46:9971006 Jozefczak M, Remans T, Vangronsveld J, Cuypers A (2012) Glutathione is a key player in metal-induced oxidative stress defenses