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A relationship between long-term metformin use and vitamin B12 deficiency has been long discussed, and many readers will have come across this in clinical practice

Other lifestyle changes that may reduce symptoms include: quitting smoking eating smaller meals not lying down for at least 2-3 hours after a meal Although people typically consider GERD to be a chronic disorder, it does not have to be permanent

is contracted via the University of Groningen (no personal payment) to undertake consultancy for Novo Nordisk, Eli Lilly and Boehringer Ingelheim

JAMA Pediatr 178 , 1307 (2024)

A separate JAMA Oncology study by Dai and colleagues (2025) found about 17% lower overall cancer incidence (hazard ratio approximately 0.83) in adults with obesity who used GLP-1 receptor agonists