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Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, et al

The regulation of COX2 expression is complex, involving transcriptional and post-transcriptional mechanisms influenced by cytokines, growth factors, and pro-inflammatory stimuli (225)

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It typically takes about 48 weeks before changes in appetite and weight become apparent, and consistent loss tends to build over months as the medication reaches its optimal effect

They activate the RAS/MAPK pathway, which promotes cell proliferation and survival (227)