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Rho GTPases in Brain Diseases Considering the critical roles of Rho GTPases in spine formation and morphology, synaptic plasticity, and memory, it is not surprising that dysfunctions in these proteins are linked to various brain diseases, some of which will be briefly discussed below

It is a 31 amino acid peptide modified for extended stability, and it is widely used in laboratory work involving incretin signaling and metabolic regulation

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In the brain, similar to other tissues, LCFA transport across membranes requires various proteins, such as fatty acid transport protein (FATP), fatty acid translocase (FAT)/CD36, plasma membrane-bound fatty acid binding protein (FABPpm), and cytosolic fatty acid-binding protein (FABPc) (123)

Using the Connectivity Map, we identified GHK as a compound that can reverse the gene-expression signature associated with emphysematous destruction and induce expression patterns consistent with TGF pathway activation