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However, excessive glucose concentrations can be detrimental, as demonstrated in studies showing metabolic stress responses in astrocytes exposed to high glucose levels

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However, the expression of NRF2 target genes appears to be correlated with the binding of NRF2 to transcriptional regulatory regions

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These substances can activate key pro-inflammatory signaling pathways such as nuclear factor kappa B (NF-B), thereby inducing the gene transcription and protein secretion of extracellular matrix (ECM) degrading enzymes like matrix metalloproteinase 13 (MMP13) and A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS5) (Miao et al., 2022