recommended dosage of glutathione & Timing for Safe Daily Use – Dr Ann Glutathione Dosage: Clinical Evidence &

"Glutathione: overview of its protective roles, measurement, and biosynthesis." Mol Aspects Med

The dismutation of O 2 . results in the formation of hydrogen peroxide (H 2 O 2 ), which can lead to elevated levels of other potentially harmful reactive oxygen and nitrogen species (ROS, RNS) 2

GCL, heterodimer made up of the heavy sub unit (73 kDa) has the catalytic activity (GCLC), and is the site of GSH feed back inhibition The light (30 kDa) or modifier (GCLM) sub unit, alter, or regulate the activity of the holoenzyme Glutamate cysteine ligase (GCL) L-glutamate + L-cysteine + ATP -L-glutamyl-L-cysteine + ADP + Pi GCL is regultate physiologically by : Feed back competitive inhibition by GSH The availability of its precurser, L-cysteine

View Guidance Milek JA, et al

Neither presents a concerning safety picture for most healthy adult researchers, though each has specific considerations worth understanding before starting