EXECUTIVE SUMMARY This brief examines the financialized business model of Novo Nordisk and Eli Lilly for the leading GLP-1 products Ozempic, Rybelsus, and Wegovy (semaglutide) and Mounjaro and Zepbound (tirzepatide)
Against DPP-IV activity, the leaves of Psoralea corylifolia (order: Fabales) contain genistein, Coffea arabica (order: Gentinales) contains caffeic acid, and Brassica oleracea (order: Brassicales) contains luteolin with IC 50 values of 0.48, 3.37, and 0.12 M, respectively ( Rosmarinus officinalis and Lippia graveolens (order: Lamiales) have cirsimaritin with IC 50 value of 0.43 and 10.9 M, respectively, which can be used for inhibition of DPP-IV activity
The evidence is mostly clinical observation and patient-reported outcomes
Anyone with diabetes should undergo regular diabetic eye screening regardless of medication type, as retinopathy can develop and progress silently without symptoms until advanced stages
In reality, those disclosures are often nonexistent, buried in hashtags or difficult to see
