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PMID: 149 Rodriguez-CarrioJLopezPSanchezBGonzalezSGueimondeMMargollesAet al

It was found that, when HKC was administered via IG at a dose of 0.75 g/Kg for 28 days, a significant decrease in the levels of BUN, serum creatinine, and urine protein in the plasma was found

The conclusions from these essentially negative MR findings have, however, been questioned in a well-argued critique 31 , pointing out the limitations of genetic markers that explain only a small component (i.e., 7.7% at most 5 ) of serum UA variance and querying whether the core assumptions of MR, including the absence of confounds as well as a strong association with UA, are met