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Limitations of Use: Tirzepatide should not be used in combination with other tirzepatide-containing products or any other GLP-1 receptor agonist The safety and efficacy of coadministration with other products for weight loss have not been established Tirzepatide has not been studied in patients with a history of pancreatitis Tirzepatide should not be used in patients with type 1 diabetes mellitus Who should not use tirzepatide

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Gerontology 66(1):214 Paccou J, Caiazzo R, Lespessailles E, Cortet B (2022) Bariatric surgery and osteoporosis

When blood glucose rises after a meal, GLP-1 and GIP both stimulate insulin secretion from pancreatic beta cells