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Biol Reprod (2016) 94(6):127

Symposium - Efficacy and safety of CagriSema 2.4 mg/2.4 mg in adults with overweight/obesity The REDEFINE 1 and REDEFINE 2 clinical trials

To identify the central mechanisms of action, a group of rats was injected systemically with fluorescently labelled exenatide, which was shown to cross the bloodbrain barrier and bind putative GLP1 receptors expressed on dopamine D 1 and D 2 receptors, expressing GABAergic medium spiny neurons in the NAc shell (Zhang et al., 2020)

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GLP-1 receptors in the brain's reward centers (ventral tegmental area and nucleus accumbens) modulate dopamine signaling