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American Journal of Endocrinol Metabolism 282: E474-E482

On the other hand, switching to an ADC with a different payload class has been shown to overcome resistance and increase antitumor efficacy: in patients with HER2+ metastatic breast cancer, switching from a TOPI inhibitor-based ADC to a microtubule inhibitor-based ADC or vice versa yielded significantly higher objective response rates and progression-free survival than sequencing two ADCs with the same payload class 248,249

It works by enhancing acetylcholine uptake in the brain, particularly in the hippocampus, which is essential for learning and memory

15 Duke Regeneration Center, Duke University School of Medicine, Durham, North Carolina, USA

Compound melanocytic naevi have a central raised area with surrounding flat pigmentation