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Example-2: Preparation of Resin bound Semaglutide backbone Step 1: Preparation of H-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)- Val-Ser(tBu)-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(Boc)- Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-Resin (3-31) Fmoc-Arg(Pbf)-OH (42.57 gm) was dissolved in DMF (125 ml) at 25-30C and HOBt (8.86 gm) and DIC (10.12 ml) were added to it

Always use a new one each time you inject

If you experience persistent headaches, fatigue, mood changes, and other symptoms that dont resolve within a few days, contact your prescribing clinician immediately to assess your condition and prevent possible complications

What works for one person may need adjustment for another

Healthcare providers will guide any transition once Ozempic tablets become available at pharmacies in Q2 2026