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Mechanistically, OGT attaches a GlcNAc moiety to the target protein [9, 10], while the hydrolase OGA catalyzes the removal of this sugar moiety [11], allowing the levels of O-GlcNAcylation to dynamically adjust in response to cellular processes [12]
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*Patients on iron tablets will have black stool, so ensure to clarify the temporal sequence for any symptoms with the starting of iron tablets Investigations Initial Investigations All patients with suspected melena should undergo routine blood tests , including FBC, U&Es, LFTs, and clotting, to help investigate for underlying causes and to stratify overall risk
Intraluminal contrast may be positive (Gastrografin or Omnipaque) or negative (usually water)
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