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For IBS patients, this mechanism is particularly relevant because IBS involves abnormal gut movement patterns and heightened visceral sensitivityboth conditions that GLP-1 agonists may help normalize

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Each dose will be analysed separately in parallel using a 2sample t test for percent change in body weight and a 2group Satterthwaite t test for change in WOMAC pain subscale score at a 2sided significance level of 0.025

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