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Supernatants from LG, HG, and HG + GIP were centrifuged at 100 x g for 5 min to remove cells and debris

184,185 The close relationship between vitamin B 12 and folate can make it difficult to distinguish their independent deficiencies: B 12 deficiency causes a functional folate deficiency by trapping folate as 5-MTHF, thereby blocking homocysteine metabolism, because B 12 is required for the conversion into functional folate

Furthermore, the multifaceted manifestations of bipolar disorder underscore the necessity to explore diverse therapeutic options

10.1186/s13287-025-04175-y 18 ChangchienC.-Y.LinY.-H.ChengY.-C.ChangH.-H.PengY.-S.ChenY

This vitamin also helps regulate GABA, an essential inhibitory agent that prevents excessive stimulation of excitation pathways in the brain leading to neuron damage