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TNF- inhibitors have long been established for the treatment of JIA, and data for treatment duration of more than 10 years is available confirming its effectiveness and tolerability in children and adolescents [63]

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The mechanism involves positive regulation of the expression of ALDHs and cytoprotective enzymes (e.g

Bertolini et al [51] reported that the number, degranulation and proliferation of perifollicular MCs are increased in human AA lesions compared to healthy or non-lesional control skin