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Efficacy and safety of LixiLan, a titratable fixed-ratio combination of Lixisenatide and insulin glargine, versus insulin glargine in type 2 diabetes inadequately controlled on metformin monotherapy: the LixiLan proof-of-concept randomized trial

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Studies exploring GLP-1 signaling have suggested potential roles in: Appetite regulation pathways Insulin response and glucose utilization Gastric emptying modulation Metabolic energy balance Mild nausea during early exposure Temporary appetite suppression Injection-site irritation Human safety profiles depend heavily on formulation and dosage, and clinical outcomes remain under ongoing investigation