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Back in 1965, Samols and his colleagues had helpfully demonstrated that the L-cells reacted with antibodies specific to glucagon which activated the release of insulin (Samols, Marri, Marks, 1965)
The structure and function of the glucagon-like peptide-1 receptor and its ligands
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We conducted the literature search on PubMed and Embase (Ovid) in December 2023 and updated it in June 2024
In a similar model, intrathecal injections of exenatide inhibited thermal hyperalgesia and mechanical allodynia by enhancing spinal microglial expression of -endorphins, IL-10 and interleukin 4 (IL-4) [34, 35]
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