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56 CORT can activate TRPV1/TRPA1 receptors through oxidative stress or direct receptor interactions, trigger calcitonin gene-related peptide (CGRP) release, promote histamine secretion, impair gastric mucosal barrier function, increase gastric acid permeability, and enhance sensitivity to reflux stimuli

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This reduction is linked to impaired differentiation of GLP-1 cells and a decrease in mature glucagon precursors

For patients with Type 2 diabetes who also have or are at high risk for cardiovascular disease, GLP-1 agonists offer a dual benefit that insulin cannot match