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Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, et al

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Measurement of plasma homocysteine should therefore be considered for patients with recurrent migraines, and patients found to have hyperhomocysteinemia should be treated accordingly

5 Metformins safety profile and clinical considerations Metformin is generally well tolerated, with gastrointestinal symptoms (nausea, diarrhea, metallic taste, flatulence) being the most common adverse effects

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