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Lineage-tracing studies using Cre recombinase systems driven by promoters active within this neuroepithelial territory, such as Wnt1 and Engrailed-1, have provided compelling evidence that progenitor cells expressing these transcription factors migrate from the ventricular zone and differentiate into MTNs (Danielian et al., 1998

doi: 10.1007/s11064-017-2362-1

Future State On March 10, 2025, OFA filed a notice of interlocutory appeal signaling their intention to appeal the March 5, 2025 decision in FDAs favor to the United States Court of Appeals for the Fifth Circuit